Abstract
The conformational restriction of a (benzylamino)methyl substituted pyrrolidine to form 2,7-diazabicyclo[3.3.0]octanes has led to a series of compounds with high affinity at the h5-HT1D receptor as well as dramatically increased concentrations in the hepatic portal vein following oral administration.
MeSH terms
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Administration, Oral
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Animals
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Bridged Bicyclo Compounds, Heterocyclic / administration & dosage
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Bridged Bicyclo Compounds, Heterocyclic / chemistry
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Bridged Bicyclo Compounds, Heterocyclic / pharmacology*
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CHO Cells
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Cricetinae
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Receptor, Serotonin, 5-HT1D
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Receptors, Serotonin / drug effects*
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Recombinant Proteins / drug effects
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Serotonin Receptor Agonists / administration & dosage
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Serotonin Receptor Agonists / chemistry
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Serotonin Receptor Agonists / pharmacology*
Substances
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Bridged Bicyclo Compounds, Heterocyclic
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Receptor, Serotonin, 5-HT1D
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Receptors, Serotonin
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Recombinant Proteins
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Serotonin Receptor Agonists